Action of Bacterial Polysaccharide on Tumors. II. Damage of Sarcoma 37 by Serum of Mice Treated With Serratia Marcescens Polysaccharide, and Induced Tolerance
W. Edward O’Malley and others, Action of Bacterial Polysaccharide on Tumors. II. Damage of Sarcoma 37 by Serum of Mice Treated With Serratia Marcescens Polysaccharide, and Induced Tolerance, JNCI: Journal of the National Cancer Institute, Volume 29, Issue 6, December 1962, Pages 1169–1175, https://doi.org/10.1093/jnci/29.6.1169
Summary
Administration of Serratia marcescens polysaccharide to normal mice was followed by the appearance of tumor-necrotizing activity in the circulating blood. Potency was assayed by intraperitoneal injection of the blood serum of treated mice into others bearing Sarcoma 37. This activity in the serum diminished rapidly; the higher the dose, the longer it persisted. Blood drawn shortly after injection of the polysaccharide possessed detectable potency following a dose as low as 20 µg. A second injection 4 days after the first one failed to produce analogous activity, even when the dose was more than doubled. This tolerance paralleled the previously reported refractoriness of tumors to repetition of treatment with the polysaccharide.
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